Biotech firm Crucell was the best performing share on the Amsterdam stock exchange in 2010, the Financieele Dagblad reports.
Crucell is listed on the MidKap index which ends the year up around 22%.
Top performer in the AEX blue chip index is civil engineering group Fugro with a rise of 53%. Dredging group Boskalis (+30%) was the second best performing AEX with airline Air France -KLM and specialty chemicals group DSM both rising 24%.
Building firm Bam was the biggest decliner, losing 22% over the year.
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